METHODS EMPLOYING BACTERIAL TOXIN-ANTITOXIN SYSTEMS FOR KILLING EUKARYOTIC CELLS

摘要

A method of inhibiting cell proliferation and/or cell cycle progression, the method comprising providing within eukaryotic cells a bacterial toxin, in particular a bacterial toxin of a post-segregational killing system such as ParD. Activity or production of toxin and/or inhibitor, e.g. antidote, are controlled for selective killing of target cells, not-target cells. Target cells include tumour cells.