| 摘要 |
A mutant virus, e.g. a herpes simplex virus, comprises a modified gene promoter, e.g. a promoter responsive to a Gal4-containing transcription factor, operably linked to an essential viral gene, e.g. an immediate early gene wherein the modified promoter is substantially non-responsive to normal virus and host transcription factors but is responsive to a heterologous transcription factor, e.g. Gal4 or a Gal4-VP16 fusion, so that said mutant virus is genetically disabled in the absence of said heterologous transcription factor. The virus can be used as a vector for delivery of a heterologous gene to a target cell.
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