摘要 |
<p>Reaction of a dialdehyde, particularly phthaldialdehyde (I), with R-Z where Z is a nucleophilic group (preferably SH) and R is polymerisable (e.g. allyl) gives a reactive thioacetal (V) which can react with an amine ligand L-NH2 to produce an isoindole (IV) which may be fluorescent. At some stage, generally before interaction with L-NH2, the R groups are polymerised, possibly leading to self-assembly of the polymer on a metal or SH-bearing surface. Such a coated surface is useful as a transducer in assays or as a binding medium e.g. for chromatography.</p> |
申请人 |
CRANFIELD UNIVERSITY;WESTON, RALPH, JOHN HM;TURNER, ANTHONY, PETER, FRANCIS;CULLEN, DAVID, CHARLES;PILETSKY, SERGIY, A.;PILETSKA, OLENA, VOLODIMIRIVNA;SCHEDLER, UWE |
发明人 |
WESTON, DAVID DI;TURNER, ANTHONY, PETER, FRANCIS;CULLEN, DAVID, CHARLES;PILETSKY, SERGIY, A.;PILETSKA, OLENA, VOLODIMIRIVNA;SCHEDLER, UWE |