发明名称 |
NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-CIS-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-YL]-SULFONYL]-3-METHOXYBENZAMIDEAND ITS SALTS |
摘要 |
The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reactio n in dimethyl sulfoxide, at a temperature between 10 ~C and 40 ~C, preferably at room temperature and transforming the resulting base of formula (I), if desired, into its salt by a method known per se.
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申请公布号 |
CA2378087(A1) |
申请公布日期 |
2001.01.25 |
申请号 |
CA20002378087 |
申请日期 |
2000.07.13 |
申请人 |
SANOFI-SYNTHELABO |
发明人 |
HERMECZ, ISTVAN;SAROSI, PETER;HALASZ, JUDIT;CSIKOS, EVA;SANTANE CSUTOR, ANDREA;NAGY, LAJOS;HEJA, GERGELY;SZOMOR, TIBORNE;SZVOBODA, GYORGYNE;MAJLATH, CSILLA;SIMON, KALMAN;GONCZI, CSABA;EROSNE TAKACSY, TUNDE POSA |
分类号 |
A61K31/5377;A61P5/12;C07B61/00;C07D209/96;(IPC1-7):C07D209/96 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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