1,5-BENZODIAZEPINE DERIVATIVES, METHOD OF THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS THEM CONTAINING

摘要

Compounds of the general formula (I) and their physiologically acceptable salts and solvates wherein X is H, CF3, alkyl, alkylthio group, -O-alkyl or halo; R1 is a group of the general formula (II) or NR4R5; R2 is a heterocycle residue, phenyl, pyridine, NHR11, optionally substituted; R3 is H, alkyl, cycloalkyl, phenyl, optionally substituted; z is 1 or 2; which compounds exhibit agonistic activity for CCK-A receptors enabling them to modulate the hormones gastrin and cholecystokinin (CCK) in mammals. There are also disclosed methods of preparing said compound of the general formula (I).