BETA-D-2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUOROCYTIDINE FOR USE IN THE TREATMENT OF HIV INFECTIONS
摘要
The present invention discloses a method for treating HIV that includes administering beta -D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70(K to N), 90 or the 172 codons of the reverse transcriptase region. Also disclosed is a method for using beta -D-D4FC as "salvage therapy" to patients which exhibit drug resistance to other anti-HIV agents. beta -D-D4FC can be used generally as salvage therapy for any patient which exhibits resistance to a drug that induces a mutation at other than the 70(K to N), 90 or the 172 codons.
申请公布号
WO0043014(A8)
申请公布日期
2001.01.18
申请号
WO2000US01738
申请日期
2000.01.21
申请人
EMORY UNIVERSITY;SCHINAZI, RAYMOND, F.;HAMMOND, JENNIFER;MELLORS, JOHN, W.;LIOTTA, DENNIS, C.
发明人
SCHINAZI, RAYMOND, F.;HAMMOND, JENNIFER;MELLORS, JOHN, W.;LIOTTA, DENNIS, C.