| 摘要 |
The invention relates to novel peptide derivatives of formula (I): Cyclo-(Arg-X<1>-Asp-X<2>-X<3>-X<4>-X<5>-X<6>-R<1>); which are biologically active as ligands of integrin alpha v beta 6, X<1> representing Ser, Gly or Thr; X<2> representing Leu, Ile, Nle, Val or Phe; X<3> representing Asp, Glu, Lys or Phe; X<4> representing Gly, Ala or Ser; X<5> representing Leu, Ile, Nle, Val or Phe; X<6> representing Arg, Har or Lys; and R<1> being left out or representing one or more omega -aminocarboxylic acid radicals, said omega -aminocarboxylic acid radical(s) being 500 to 2500 pm in length. Said amino acids can also be derivatised and the D and L forms of the optically active amino acid radicals are enclosed. The invention also relates to the physiologically suitable salts and solvates of the inventive derivatives.
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