| 摘要 |
A preventive and curative agent for inflammatory bowel diseases is disclosed which has as an active ingredient thereof a chromanol glucoside represented by the following general formula (1)(wherein R1, R2, R3, and R4 represent identically or differently either a hydrogen atom or a lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group, X represents a monosaccharide residue or an oligosaccharide residue having the hydrogen atom in the hydroxyl group thereof optionally substituted with a lower alkyl group or a lower acyl group, n represents an integer of 0-6, and m represents an integer of 1-6).Owing to the use, as an active ingredient, of the chromanol glucoside excelling in water solubility and possessing an oxidization resisting action and a free radical resisting action, the agent can conspicuously repress the lesion of an inflammatory bowel disease and prominently ameriolate the condition of disease. It can be manufactured into an aqueous preparation containing the active ingredient in a high concentration and, therefore, act effectively on the seat of disease at a low application rate, and prevent and cure the inflammatory bowel diseases. It further allows very safe use because it entails no side effect.
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