| 摘要 |
Methods and compositions for the induction of immune tolerance in mammalian antigen presenting cells such as dendritic cells, macrophages, monocytes and B- lymphocytes are described. Such methods and compositions involve the use of agonists of the cell surface receptors CD36, CD51, thrombospondin receptors and/or the .beta.-integrins which when exposed to an antigen-presenting cell such as a dendritic cell are able to inhibit maturation therein. Thus, the cells' ability to promote an immune response is inhibited. Tolerance to a specific antigen can be induced in antigen-presenting cells by exposure to o ne or more of the aforesaid agonists and the antigen. Thus, cell preparations c an be prepared for administration to humans where tolerance to a specific antig en or antigens needs to be induced, for example in the case of allograft or xenograft transplants or in autoimmune disease.
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