| 发明名称 |
Inhibitors of prenyl-protein transferase |
| 摘要 |
The present invention is directed to conformationally constrained compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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| 申请公布号 |
US6172076(B1) |
申请公布日期 |
2001.01.09 |
| 申请号 |
US19990332769 |
申请日期 |
1999.06.14 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
EMBREY MARK W.;WAI JOHN S.;PERLOW DEBRA S.;HOFFMAN JACOB M. |
| 分类号 |
C07D401/06;C07D471/10;C07D498/10;C07D513/10;(IPC1-7):A61K31/438;C07D487/10 |
主分类号 |
C07D401/06 |
| 代理机构 |
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| 主权项 |
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