发明名称 |
CYCLIC AMP PHOSPHODIESTERASE ISOFORMS AND METHODS OF USE |
摘要 |
Human and rat cAMP phosphodiesterase isoforms (denoted PDE4Ds), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the PDE4Ds (denoted PDE4D6) disclosed herein as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
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申请公布号 |
WO0100851(A1) |
申请公布日期 |
2001.01.04 |
申请号 |
WO2000US17369 |
申请日期 |
2000.06.23 |
申请人 |
MEMORY PHARMACEUTICAL CORPORATION |
发明人 |
XIN, XIAONAN;UNTERBECK, AXEL;HU, YINGHE |
分类号 |
A01K67/027;C07K7/08;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N15/09;C12N15/55;C12P21/08;C12Q1/02;C12Q1/34;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):C12N15/55;C12N15/866;C12Q1/44 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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