1-(4-arylsulfonyl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2

摘要

Compounds of formula (I) are provided wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; and Q is selected from the group consisting of substituted and unsubstituted phenyl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating inflammation and cyclooxygenase-mediated disorders.