Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders

摘要

The compounds of formula I may be used for the treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers. In formula I; Ar1 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonamide; Ar2 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by lower alkyl or halogen; X is C, CH, C(OH) or N; Y is -CH2-, CH or O; Z -CH2-, -CH(CH3)- or -C(CH3)2-; R1 is hydrogen, lower alkyl or acetyl; A is C=O or -(CHR2)n-, wherein R2 is hydrogen, lower alkyl or hydroxy-lower alkyl; B is -(CH2)n-, O, -CH(OH)(CH2)n-, -CH(CH2OH)(CH2)n-, -(CH2)n CH(OH)- or -CH(CH2OH)-; --- may be a bond, and n is 0-4