| 摘要 |
<p>The present invention relates to nucleic acids encoding a protein, which is an epidermal growth factor receptor (EGFR)-ligand having e.g. no heparin binding site. Preferably, the protein is capable of stimulating astroglial cell maturation and/or has a selective survival promoting activity on dopaminergic (DAergic) and/or peripheral neurons and/or has a regenerative effect on peripheral and axonal neurons. The present invention further relates to antisense nucleic acids, ribozymes and antibodies directed to the nucleic acid or the protein, to methods of their production, to antagonists directed to the protein, to agonists which substitute the functional activity of the protein and to pharmaceutical compositions for the treatment as well as to diagnostic kits for the detection of disorders such as neurodegenerative diseases, cancer and AIDS.</p> |
