| 摘要 |
The invention relates to a method for inducing tolerance to an adenoviral vector and/or transgene product in a host, thereby allowing persistent transgene expression in the host and allowing repeated vector administration to the host while minimizing or eliminating the host immune response. The method comprises pretreating a host by administering to the host adenoviral vector-infected antigen presenting cells wherein said adenoviral vector comprises heterologous nucleic acids encoding an immunomodulatory molecule and a transgene and wherein said adenoviral vector-infected antigen presenting cells migrate to lymphoid organs and/or lymph nodes and induce tolerance. The method further provides for subsequentadministration to the host of an adenoviral vector comprising a heterologous nucleic acid encoding said transgene wherein the host immune response is reduced or eliminated to said adenoviral vector and said transgene even upon repeated administration of said adenoviral vector. |
