NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES

摘要

Nitrogenous six-membered heterocycle compounds bearing as the substituents -X-A-R<3>, -N-(R<1>)-(R<2>-substituted Ph) and -CONH2; salts or prodrugs thereof; and Syk inhibitors containing the compounds, the salts or the prodrugs as the active ingredient, wherein A is (substituted) lower alkylene, (substituted) arylene, or the like; X is NR<4>, CONR<4>, NR<4>CO, O, or S; R<1> and R<4> are each H, lower alkyl, -CO-lower alkyl, or -SO2-lower alkyl; R<2> is H, (substituted) lower alkyl, -O-lower alkyl, -S-lower alkyl, -O-aryl, nitro, cyano, or the like; and R<3> is -CO2H, -CO2-lower alkyl, -lower alkylene-CO2H, -NH2, -alkylene-NH2, or the like.