DETECTION OF DRUG RESISTANT ORGANISMS

摘要

A method is disclosed for detecting drug resistance in a strain of an organism. In the method the presence of at least one mutation in a predetermined region within the gene of the strain is detected. The predetermined region has a multiplicity of mutations among strains of the organism that differ from a corresponding region of the wild type strain of the organism. To detect the mutation, a complex is formed comprising the predetermined region of the gene of the organism and the corresponding region of the gene of the wild type organism in double stranded form. Each member of at least one pair of non-complementary strands within the complex has a label. The association of the labels within the complex is detected wherein the association of the labels in the complex is related to the presence of the mutation. The presence of the mutation is related to the drug resistance of the strain.