PROCESS FOR THE PRODUCTION OF AMORPHOUS ATORVASTATIN CALCIUM
摘要
<p>A process for the preparation of amorphous atorvastatin calcium and hydrates thereof which comprises: (a) dissolving crystalline atorvastatin calcium in a non-hydroxylic solvent; (b) adding a non-polar hydrocarbon anti-solvent or adding the dissolved atorvastatin to the non-polar anti-solvent to precipitate out atorvastatin calcium; and (c) removing the solvent by filtration to afford amorphous atorvastatin calcium.</p>
申请公布号
WO0071116(A1)
申请公布日期
2000.11.30
申请号
WO2000IB00014
申请日期
2000.01.06
申请人
RANBAXY LABORATORIES LIMITED;KUMAR, YATENDRA;THAPER, RAJESH, KUMAR;KUMAR, S., M., DILEEP
发明人
KUMAR, YATENDRA;THAPER, RAJESH, KUMAR;KUMAR, S., M., DILEEP