| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing cis-1- 2-[4-(6-methoxy-2- phenyl-1,2,3,4-thetrahyfronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine effective in treating osteoporosis. SOLUTION: 2-Bromo-5-methoxy-toluene is brominated to form 1-bromo-2- bromomethyl-4-methoxy-benzene. Thereby, this method for producing cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl) phenoxy]ethyl}pyrrolidine is started to provide a ketone 3-(2-bromo-5-methoxy- phenyl)-1-phenyl-propan-1-one by alkylation of ethyl benzoylacetate by benzoyl bromide and the subsequent decarboxylation. As a result, the cis-1- 2-[4-(6- methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]-ethyl}-pyr rolidine which is an intermediate for producing (-) cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl- ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol is produced. |
