| 摘要 |
The present invention is directed to polymeric- prodrug transport forms of the formula: wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or wherein B1 is a leaving group, OH or a residue of a hydroxyl-containing moiety; Y1-2 are independently O or S; M is selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y2); R2-5 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls and substituted C1-6 heteroalkyls; (m) is zero or one; (n) is a positive integer; (p) is zero or a positive integer; Z is an electron withdrawing group; and R1 is a polymeric residue which is optionally capped with a moiety of the Formula (v)
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