| 发明名称 |
Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same |
| 摘要 |
PCT No. PCT/US96/00519 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed Jan. 11, 1996 PCT Pub. No. WO96/21435 PCT Pub. Date Jul. 18, 1996Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram as well as with improved selectivity with regard to PDE III inhibition. In certain aspects of the invention, the compounds also demonstrate PDE V inhibition. Pharmaceutical compositions containing the same and methods of treatment are also disclosed.
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| 申请公布号 |
US6153630(A) |
申请公布日期 |
2000.11.28 |
| 申请号 |
US19970875487 |
申请日期 |
1997.11.13 |
| 申请人 |
EURO-CELTIQUE, S.A. |
发明人 |
CAVALLA, DAVID J.;CHASIN, MARK;DOLBY, LLOYD |
| 分类号 |
C07D239/52;A61K31/12;A61K31/135;A61K31/15;A61K31/165;A61K31/41;A61K31/415;A61K31/4164;A61K31/4166;A61K31/42;A61K31/421;A61K31/4245;A61K31/433;A61K31/44;A61K31/4409;A61K31/505;A61P11/00;A61P11/06;A61P29/00;A61P37/00;A61P37/08;A61P43/00;C07C45/30;C07C235/38;C07C271/00;C07C271/60;C07D213/02;C07D213/73;C07D213/74;C07D231/12;C07D231/14;C07D231/20;C07D231/38;C07D233/20;C07D233/54;C07D233/64;C07D233/72;C07D233/78;C07D233/88;C07D233/90;C07D239/54;C07D249/04;C07D249/08;C07D249/14;C07D263/34;C07D271/02;C07D275/02;C07D277/10;C07D277/20;C07D277/22;C07D277/24;C07D277/26;C07D277/34;C07D277/38;C07D277/42;C07D285/04;(IPC1-7):A61K31/44 |
主分类号 |
C07D239/52 |
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