INTERACTION BETWEEN THE VHL TUMOUR SUPPRESSOR AND HYPOXIA INDUCIBLE FACTOR, AND ASSAY METHODS RELATING THERETO

摘要

The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor alpha subunits, by targeting HIF alpha for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF alpha subunit sequences which may modulate this interaction.