MUTANT ACTINOPLANES TEICHOMYCETICUS MSL 2211 AND TEICOPLANIN PRODUCED THEREFROM

摘要

PURPOSE: A mutant Actinoplanes teichomyceticus MSL 2211 is provided which mass produces teicoplanin under the optimum culture condition. Also, a preparation method of teicoplanin is provided. CONSTITUTION: An Actinoplanes teichomyceticus MSL 2211(KCTC 8926p) is characterized by showing a high productivity of teicoplanin. A culture medium of Actinoplanes teichomyceticus MSL 2211 is characterized by comprising 75-85 wt.% of saccharobiose, 10-20 wt.% of yeast extract, 2-5 wt.% of amino acid, 2.2-5 wt.% of inorganic salt. The saccharobiose is characterized by comprising a mannose. The amino acid is characterized by comprising asparagine. The inorganic salt is characterized by comprising magnesium 2-4 wt.% of sulfate, 0.1-0.5 wt.% of sodium chloride, 0.1-0.5 wt.% of calcium chloride.