发明名称 |
Eukaryotic IMPDH polynucleotide and antibody compositions |
摘要 |
Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.
|
申请公布号 |
US6147194(A) |
申请公布日期 |
2000.11.14 |
申请号 |
US19970925230 |
申请日期 |
1997.09.08 |
申请人 |
ARCH DEVELOPMENT CORPORATION |
发明人 |
COLLART, FRANK R.;HUBERMAN, ELIEZER |
分类号 |
A61K48/00;C07K16/40;C12N1/21;C12N9/04;C12N15/53;C12P19/32;(IPC1-7):C07K16/00;C12N9/64 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|