Use of a synergistic mixture of polyphenols and vitamin compounds in cosmetic and dermatological compositions and methods for capturing free radicals on the skin and skin appendices

摘要

The use of a synergistic mixture of polyphenols and vitamin compounds in cosmetic and dermatological compositions for optimised capture of free radicals on the skin and skin appendices requires a specific study of the capture of free radicals such as hydroxyl radical and/or such as superoxide anion and/or peroxylipid radical in validated in vitro models so as to know the real capture behaviour of each of the active principles of the proposed mixture; depending on the quantified results it is possible to determine the reciprocal proportions of each of the constituents. An in vitro study providing the percentage of respective cutaneous penetration specific to each constituent of the synergistic mixture enables an optimal galenical formulation. It is possible to establish a standard galenical formulation of the various polyphenolic and vitamin constituents so as to actually obtain synergy in the capture of free radicals in vivo. Among several mixtures a combination of troxerutine, alpha -tocopheryl succinate and ascorbyl palmitate has been studied in particular.