发明名称 |
Effects of 17 alpha -dihydroequilenin on plasma lipid and lipoprotein, glucose, insulin concentrations, coronary artery vasomotor function, and reproductive organ and mammary gland proliferation in atherosclerotic mammals |
摘要 |
The present invention relates to a method of using 17 alpha -dihydroequilenin and metabolic conjugates thereof to prevent and reduce atherogenesis in males and females without causing endometrial proliferation in females and without producing feminizing changes in males. 17 alpha -dihydroequilenin was evaluated for its effects on plasma lipid and lipoprotein, glucose, insulin concentrations, coronary artery vasomotor function, and reproductive organ and mammary gland proliferation in atherosclerotic mammals. 17 alpha -dihydroequilenin was found to prevent endothelium-dependent vasoconstriction in males (p<0.05) and ovariectomized females (p<0.08). 17 alpha -dihydroequilenin treatment increased plasma apolipoprotein A-1 concentrations (p<0.05) and lowered fasting insulin concentrations (p<0.05) without changing fasting plasma glucose concentrations in males. 17 alpha -dihydroequilenin had no other effects on plasma lipid and lipoprotein concentrations in either males or females. Also, 17 alpha -dihydroequilenin exhibited no trophic effects on the uterus, endometrium, or breast, and no effect on either prostatic or testicular weight. Thus, 17 alpha -dihydroequilenin may prevent breast and prostatic hyperplasia and neoplasia, and has no feminizing effects on the male urogenital system or mammary gland.
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申请公布号 |
US6147069(A) |
申请公布日期 |
2000.11.14 |
申请号 |
US19990391985 |
申请日期 |
1999.09.09 |
申请人 |
WAKE FOREST UNIVERSITY;AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
WASHBURN, SCOTT A.;CLARKSON, THOMAS B.;ADAMS, MICHAEL R.;REGISTER, THOMAS C.;WILLIAMS, J. KOUDY;WAGNER, JANICE D.;CLINE, J. MARK;ADELMAN, STEVEN J. |
分类号 |
A61K31/56;A61K31/567;(IPC1-7):A61K31/56 |
主分类号 |
A61K31/56 |
代理机构 |
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