发明名称 |
Antibody and polyalkylene glycol-bonded liposome |
摘要 |
A liposome wherein a compound containing a polyalkylene glycol moiety is bonded through a thioether group and an antibody is bonded through a thioether group to a liposome comprising lipids whose partial component has maleimidated terminal, wherein an amount of the bonded compound and an amount of bonded antibody is 15 to 50 mole% and 0.1 to 2 mole%, respectively, based on one mole of the maleimidated lipid contained in the liposome. The liposome achieves both excellent blood retention and therapeutic effect. |
申请公布号 |
AU3840700(A) |
申请公布日期 |
2000.11.10 |
申请号 |
AU20000038407 |
申请日期 |
2000.04.20 |
申请人 |
MITSUBISHI CHEMICAL CORPORATION |
发明人 |
TOSHIAKI TAGAWA;SAIKO HOSOKAWA |
分类号 |
A61K9/127;A61K31/704;A61K47/48;A61P35/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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