发明名称 |
CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF |
摘要 |
Compounds of general formula (I) or salts thereof, which exhibit excellent CCR5 antagonism and are useful as preventive or therapeutic drugs for HIV infection of human peripheral blood monocytes, particularly AIDS. In said formula R<1> is hydrocarbyl and R<2> is hydrocarbyl having two or more carbon atoms, or R<1> and R<2> together with the nitrogen atom adjacent thereto may form a ring which may be substituted; R<3> is optionally substituted hydrocarbyl or a heterocyclic group; R<4> is hydrogen, hydrocarbyl, a heterocyclic group, or the like; E is a divalent chain hydrocarbon group or the like; G is CO or SO2; J is nitrogen, a methyne group, or the like; and Q and R are each a divalent C1-C3 chain hydrocarbon group or the like.
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申请公布号 |
WO0066551(A1) |
申请公布日期 |
2000.11.09 |
申请号 |
WO2000JP02765 |
申请日期 |
2000.04.27 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;ISHIHARA, YUJI;IMAMURA, SHINICHI;HASHIGUCHI, SHOHEI;NISHIMURA, OSAMU;KANZAKI, NAOYUKI;BABA, MASANORI |
发明人 |
ISHIHARA, YUJI;IMAMURA, SHINICHI;HASHIGUCHI, SHOHEI;NISHIMURA, OSAMU;KANZAKI, NAOYUKI;BABA, MASANORI |
分类号 |
A61P31/18;A61P43/00;C07D207/26;C07D207/277;C07D211/18;C07D211/26;C07D211/32;C07D211/52;C07D211/78;C07D265/30;C07D401/06;C07D401/12;C07D401/14;C07D403/12;C07D405/06;C07D405/12;C07D405/14;C07D413/14;(IPC1-7):C07D207/277;C07D403/06;C07D413/06;A61K31/401;A61K31/454;A61K31/496;A61K31/537;A61K31/55 |
主分类号 |
A61P31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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