发明名称 |
GENES INTEGRATING SIGNAL TRANSDUCTION PATHWAYS |
摘要 |
The present invention describes the identification, isolation, sequencing and characterization of two human CalDAG-GEF, and two human cAMP-GEF genes, which are associated with the Ras pathway. Also identified are CalDAG-GEF gene homologues in mice and cAMP-GEF gene homologues in rats. Nucleic acids and proteins comprising or derived from the CalDAG-GEFs and/or cAMP-GEFs are useful in screening and diagnosing certain Ras-associated cancers, in identifying and developing therapeutics for treatment of certain Ras-associated cancers, and in producing cell lines and transgenic animals useful as models of Ras-associated cancers. |
申请公布号 |
WO0024768(A3) |
申请公布日期 |
2000.11.09 |
申请号 |
WO1999US24826 |
申请日期 |
1999.10.22 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;KAWASAKI, HIROAKI;GRAYBIEL, ANN;HOUSMAN, DAVID |
发明人 |
KAWASAKI, HIROAKI;GRAYBIEL, ANN;HOUSMAN, DAVID |
分类号 |
A61K38/00;C07K14/82 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|