HALO DERIVATIVES OF 9-DEOXO-9A-AZA-9A-HOMERYTHROMYCIN A

摘要

The invention relates to halo derivatives of 9a-N-(N'-arylcarbamoyl)- and 9a -N- (N'- arylthiocarbamoyl) -9- deoxo-9a-aza-9a-homoerythromycin A of general formula (I) wherein R has the meaning of a substituted aryl group of formula (II) wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a(C1-C6)haloalkyl or a (C1- C6)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen , halo, a (C1-C6)alkyl or a (C1-C6)alkoxy group, and X has the meaning of oxyg en or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for the preparation, of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.