发明名称 |
ASSAY FOR PREDICTING THE ANGIOGRAPHIC RESPONSE TO LIPID-LOWERING THERAPY IN PATIENTS |
摘要 |
The present invention relates to an assay for testing the genetic predisposition to respond to lipid-lowering therapy in patients with coronary artery disease (CAD), comprising identifying the presence or absence of a TaqIB restriction site in intron 1 in both alleles of the cholesteryl ester transfer protein (CETP) gene by suitable molecular biological techniques; and correlating the presence of the restriction site on one or both alleles with a high or intermediate, susceptibility for lipid-lowering therapy. The invention further relates to a testkit for performing the assay and to a cholesterol ester transfer protein (CETP) gene marker for identifying individuals that may or may not be susceptible for lipid-lowering therapies. |
申请公布号 |
EP1049805(A2) |
申请公布日期 |
2000.11.08 |
申请号 |
EP19990902536 |
申请日期 |
1999.01.06 |
申请人 |
ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM |
发明人 |
KUIVENHOVEN, JAN, ALBERT;KASTELEIN, JOHANNES, JACOBUS, PIETER |
分类号 |
C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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