| 摘要 |
PCT No. PCT/JP98/00992 Sec. 371 Date Sep. 20, 1999 Sec. 102(e) Date Sep. 20, 1999 PCT Filed Mar. 11, 1998 PCT Pub. No. WO98/42714 PCT Pub. Date Oct. 1, 1998The Sesquiterpene derivatives are useful as antivirus agents, which are shown by the formula: wherein R1 is hydrogen or halogen; and R2 is hydrogen, halogen, -OR7 (wherein R7 is hydrogen etc.) or -NHR8 (wherein R8 is hydrogen etc.) etc., or R1 and R2 taken together may form oxo or =NR9 (wherein R9 is hydroxy etc.); R3 is hydrogen or halogen; R4 is hydrogen, halogen, -OR10 (wherein R10 is hydrogen etc.), or -NHR11 (wherein R11 is hydrogen etc.), or R3 and R4 taken together may form oxo or =NR12 (wherein R12 is hydroxy etc.) or R2 and R4 taken together may form an unsaturated bond or -O-; A is =NR5 (wherein R5 is hydrogen, lower alkyl etc.) R6 is hydrogen, cyano etc., X is hydrogen, cyano etc., Y1 and Y2 are both hydrogens, or taken together may form oxo; Z1 and Z2 are both hydrogens, or taken together may form oxo, or Z1 is hydrogen and Z2 is hydroxy etc.
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