COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY SELECTIVELYINHIBITING VEGF

摘要

Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due t o their specificity. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate and prodrug compositions a nd methods using the new VEGF-specific antibodies are also provided.