发明名称 |
PROSTHETIC GRAFTS |
摘要 |
An improved prosthetic graft for the bypass, replacement or repair of vessel s and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at lea st one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft. |
申请公布号 |
CA2368253(A1) |
申请公布日期 |
2000.11.02 |
申请号 |
CA20002368253 |
申请日期 |
2000.04.27 |
申请人 |
SULZER BIOLOGICS, INC. |
发明人 |
ANDERSON, DIANE LEE;SCOCCIANTI, MARCO;FACCHIANO, ANTONIO;COLOGNESI, MAURIZIO CAPOGROSSI;RANIERI, JOHN PAUL |
分类号 |
A61F2/06;A61K35/12;A61K48/00;A61L27/38;A61L27/50;C12N5/02;C12N5/077;(IPC1-7):A61F2/06 |
主分类号 |
A61F2/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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