发明名称 |
Replication-competent Herpes simplex virus mediates destruction of neplastic cells |
摘要 |
A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the gamma 34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.
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申请公布号 |
US6139834(A) |
申请公布日期 |
2000.10.31 |
申请号 |
US19980004511 |
申请日期 |
1998.01.08 |
申请人 |
GEORGETOWN UNIVERSITY |
发明人 |
MARTUZA, ROBERT L.;RABKIN, SAMUEL D.;MINETA, TOSHIHIRO |
分类号 |
A61K35/76;C12N15/869;(IPC1-7):A01N63/00;A61K48/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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