发明名称 |
Control of infectious microorganisms by modulation of chorionic gonadotropin-related protein activity |
摘要 |
A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by administering to the warm-blooded animal an effective amount of an antibody capable of inhibiting the activity of the protein, the chorionic gonadotropin-like growth-regulating protein itself such that the animal develops a neutralizing immune response, or peptides that block the receptors of the chorionic gonadotropin-like growth-regulating protein in the infectious microorganism. Candida albicans is one such microorganism that can be controlled by delivering an antibody against the growth-regulating protein, CaCGLP. Mycobacteria can also be controlled by this method. A method of inhibiting transition of Candida albicans blastospores in vitro by contacting the blastospores with an antibody against CaCGLP is also disclosed. A method of inhibiting growth of mycobacteria in vitro comprises contacting the mycobacteria with an antibody against an endogenous chorionic gonadotropin-like growth-regulating protein. In vitro growth of microorganisms can also be stimulated by contacting the microorganism with a chorionic gonadotropin-like growth-regulating protein.
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申请公布号 |
US6139839(A) |
申请公布日期 |
2000.10.31 |
申请号 |
US19980158565 |
申请日期 |
1998.09.22 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
ODELL, WILLIAM D.;GRIFFIN, JEANINE T.;GROVER, SANJEEV;CATICHA, OMAR;CARRELL, DOUGLAS T.;WOODS, II, MARION L. |
分类号 |
A61K38/00;A61P5/02;A61P31/04;C07K16/26;(IPC1-7):A61K39/395;A61K39/00;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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