发明名称 |
PROCESS OF CONJUGATION OF ANTIVIRAL NUCLEOSIDES WITH LACTOSAMINATED HUMAN ALBUMIN. |
摘要 |
<p>PCT No. PCT/EP93/03261 Sec. 371 Date Sep. 30, 1994 Sec. 102(e) Date Sep. 30, 1994 PCT Filed Nov. 20, 1993 PCT Pub. No. WO94/12218 PCT Pub. Date Jun. 9, 1994A conjugate of an antiviral nucleoside with a lactosaminated human albumin (L-HSA) and its method of preparation is described. The method of preparation involves the reaction of an antiviral phosphorylated nucleoside in the form of an imidizolide with L-HSA at a pH above 7.5 and running the reaction until the desired molar ratio of drug to L-HSA is obtained.</p> |
申请公布号 |
GR3033611(T3) |
申请公布日期 |
2000.10.31 |
申请号 |
GR20000401297T |
申请日期 |
2000.06.07 |
申请人 |
LABORATORI BALDACCI SPA |
发明人 |
FIUME, LUIGI;BUSI, CORRADO;DI STEFANO, GIUSEPPINA;MATTIOLI, ALESSANDRO |
分类号 |
A61K47/48;(IPC1-7):A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|