PROTEASE ACTIVATED RECEPTOR 2 VARIANTS

摘要

A variant PAR-2 receptor polypeptide or a fragment thereof is provided which (i) has reduced sensitivity to trypsin as compared with wild type PAR-2; (ii) has increased sensitivity to trans-cinnamoyl-LIGRLO-NH2 as compared with wild type PAR-2; and (iii) is activated by TLIGRL-NH2, which polypeptide or fragment thereof comprises an extracellular loop 2 (ECL-2) having at least one amino acid difference from the corresponding ECL-2 amino acid sequence of the wild type polypeptide.