Applying materials to a support, useful for combinatorial synthesis of peptides, e.g. for diagnosis, by incorporating materials in meltable particles and delivery through a printer

摘要

Applying substances (I), especially monomers for combinatorial synthesis of molecule libraries, to a carrier by embedding (I) in a matrix, an applying the matrix to the carrier either as a solid or a gel, is new. (I) is first embedded in a matrix comprising /- 1 first solvent (S1) that is solid at below 90 (preferably 50) deg C so as to form transport units (TU) that can be moved individually. TU are applied to the carrier as solid, at below 90 deg C or are applied dissolved in second solvent (S2), which at the same temperature is a liquid, so that, after evaporating /- some S2, a solid or gel is formed on the carrier. (I) is then rendered mobile by altering the physical conditions, brought into contact with the carrier surface by a physical process and coupled covalently to molecules (II) on the surface (or it undergoes, or catalyzes, a reaction with (II)). Coupled (I) may be (or may generate) many different substances and application of (I) can be repeated sequentially, with intermediate rinsing off of any uncoupled (I). An Independent claim is also included for an apparatus for the process.