ANTI-MCP-1 ANTIBODY RECOGNIZING PEPTIDE MIMICS, THEIR PRODUCTION AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To produce peptide mimics capable of controlling and regulating the interaction of MCP-1 regarded as closely participating in the migration of a monocyte with an receptor thereof. SOLUTION: The peptide mimics are capable of controlling and regulating the interaction of MCP-1 closely participating in the migration of a monocyte with a receptor thereof. The pharmaceutical composition and a monocyte migration inhibitor comprise the peptide mimics. The method for producing the peptide mimics comprises screening a phage random peptide library with an anti- MCP-1 antibody. The peptide mimics are useful as a monocyte migration inhibitor and can be expected for supply to various inflammatory diseases.