This invention is directed to a new approach to form porous hydrogel materials by first creating gas pockets in the gel and then removing this gas. The removal of the gas creates a porous material, and the initial incorporation of sufficient gas allows one to create a material with an open, interconnected pore structure. Advantageous features of the resulting materials, in addition to their interconnected pore structure, may include that the pore structure is maintained over extended time periods and that the gels maintain a high mechanical integrity that allows seeding with cells and implantation without destruction or compression of the material.
申请公布号
WO0061668(A1)
申请公布日期
2000.10.19
申请号
WO2000US09466
申请日期
2000.04.10
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;EISELT, PETRA;HALBERSTADT, CRAIG;MOONEY, DAVID;YEH, JULIA;LATVALA, RACHEL;ROWLEY, JON, A.
发明人
EISELT, PETRA;HALBERSTADT, CRAIG;MOONEY, DAVID;YEH, JULIA;LATVALA, RACHEL;ROWLEY, JON, A.