| 发明名称 |
Recombinant antibody-enzyme fusion proteins |
| 摘要 |
The invention is related to recombinantly produced fusion polypeptides comprising antibody VH and VL sequences operatively linked to a beta -lactamase for use in the delivery of cytotoxic drugs to tumor cells.
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| 申请公布号 |
US6132722(A) |
申请公布日期 |
2000.10.17 |
| 申请号 |
US19980070637 |
申请日期 |
1998.04.30 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SIEMERS, NATHAN O.;YARNOLD, SUSAN;SENTER, PETER D. |
| 分类号 |
C12N15/09;A61K31/131;A61K31/337;A61K31/407;A61K31/704;A61K38/00;A61K45/06;A61K47/48;A61P35/00;A61P43/00;C07K16/30;C07K19/00;C12N9/78;(IPC1-7):A61K39/395;A61K47/16;C12N9/96 |
主分类号 |
C12N15/09 |
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