METHOD FOR THE ACYLATION OF THE 7-AMINO GROUP OF THE CEPHALOSPORANIC RING

摘要

PURPOSE: A method for acylating a 7-amino group of a cephalosporanic ring is provided to specifically remove a protective group of 7-amino group from a cephalosporanic ring and to be economically advantageous. CONSTITUTION: The method for acylating a 7-amino group of a cephalosporanic ring comprises the steps of: acylating a protected amino group of a cephalosporanic ring with unsubstituted or substituted aminothiazolyl acetic acid; deprotecting the protected amino group to prepare 7-ACA amino thiazolyl protected adduct. Particularly, the protective group of amino is selected from the group consisting of phenyl acetyl and phenoxy acetyl, and the deprotecting step is conducted by hydrolysis in an aqueous solution at a temperature of 0 to 50 deg.C and at a pH of 5 to 9 in the presence of an enzyme selected from the group consisting of penicillin G amidase and penicillin V amidase respectively.