PROCESS FOR PRODUCING SUBUNIT PEPTIDE ORIGINTAING IN POLYMER PROTEIN

摘要

A process for producing a subunit peptide originating in a polymer protein which has disulfide bonds in a subunit and between subunits. This process involves the following steps: (a) the step of denaturing the polymer protein or its subunit by using a protein denaturing agent in a solution, and then eliminating the denaturing agent from the solution in the presence of a polyoxyalkyl polyether having a functional group reacting with a thiol group, thereby unwinding the subunit; and (b) the step of separating the subunit, to which the polyoxyalkyl polyether has been bonded, from the solution.