发明名称 |
PYRIDAZINE DERIVATIVES AND MEDICAMENTS CONTAINING THEM AS ACTIVE INGREDIENT |
摘要 |
<p>This invention relates to pyridazine derivatives represented by the formula (1): <CHEM> wherein R<1> represents a (substituted) aryl group, R<2> represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R<3> represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1 beta production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.</p> |
申请公布号 |
EP1043317(A1) |
申请公布日期 |
2000.10.11 |
申请号 |
EP19980951732 |
申请日期 |
1998.11.09 |
申请人 |
KOWA CO., LTD. |
发明人 |
OHKUCHI, MASAO;KYOTANI, YOSHINORI;SHIGYO, HIROMICHI;KOSHI, TOMOYUKI;KITAMURA, TAKAHIRO;OHGIYA, TADAAKI;MATSUDA, TAKAYUKI;YAMAZAKI, YUKIYOSHI;KUMAI, NATSUYO;KOTAKI, KYOKO;YOSHIZAKI, HIDEO;HABATA, YURIKO |
分类号 |
A61K31/50;A61K31/501;A61P19/02;A61P19/10;A61P29/00;A61P37/00;C07D213/00;C07D237/00;C07D237/04;C07D237/14;C07D237/18;C07D401/04;C07D401/06;(IPC1-7):C07D237/04 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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