| 摘要 |
PROBLEM TO BE SOLVED: To obtain a 1,4-bis(chlorodifluoromethyl)benzene useful as an intermediate for medicaments and agrochemicals, raw materials for functional substances or the like in a good yield by the chlorination of a bis(difluoromethyl)benzene with chlorine in the presence of a radical polymerization initiator. SOLUTION: By the chlorination of 1 mol, 1,4-bis(difluoromethyl)benzene with >=2 mol supply chlorine in the presence of (preferably 0.00001-0.05 mol) radical polymerization initiator at preferably the reaction temperature of 0-120 deg.C and the reaction pressure of 1-3 kg/cm2. The radical polymerization initiator is preferably an azo-based initiator (e.g. azobisisobutyronitrile or the like). The reaction may be carried out in the presence of a solvent (e.g. carbon tetrachloride or the like) and a reactor having lining made of glass, stainless steel or the like is employed as the reaction zone. The contacting method may be e.g. flow-through-type, batch-type or the like. The obtained compound can be purified by distillation or the like to impart a high purity product.
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