摘要 |
Oligopeptides wherein aa1 denotes the amino acid in the N-terminus; aa2 denotes the amino acid in the C-terminus, and, X denotes an stretch of 2 to 8 identical or different amino acids, located between aa1 and aa2, and their pharmaceutically acceptable salts, which satisfy the condition that at least, 3 of the amino acids are basic or positively-charged, and at least one is an aromatic amino acid. These oligopeptides block the ionic channels that are activated by noxious stimuli such as exogenous chemical substances, thermal stimuli or inflammatory mediators, for example, the VR1 channel. These peptides are appropriate to treat or attenuate disorders mediated by the activity of this receptor, for example, pain. aa1-X-aa2 |