| 摘要 |
Disclosed are MC-4 and/or MC-3 receptor ligands having a structure according to Formula (I): wherein B, X, Z, D, G, R, R1, R1', R11, m, n, p, and q are a s described in the specification. The compounds are useful in treating disease s that are mediated by the MC-4 and/or the MC-3 receptor. As such, the inventi on is directed to methods of treating body weight disorders, such as obesity, anorexia, and cachexia. The invention also relates to the treatment of CNS depression, behavior-related disorders, memory-related disorders, cardiovascular function, inflammation, sepsis, septic shock, cardiogenic shock, hypovolemic shock, sexual dysfunction, erectile dysfunction, muscle atrophy, diseases associated with nerve growth and repair, and intrauterine fetal growth. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I).
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