发明名称 |
Sulfonamide inhibitors of aspartyl protease |
摘要 |
PCT No. PCT/US95/02420 Sec. 371 Date Apr. 1, 1996 Sec. 102(e) Date Apr. 1, 1996 PCT Filed Feb. 24, 1995 PCT Pub. No. WO95/24385 PCT Pub. Date Sep. 14, 1995This invention provides a novel class of sulfonamide compounds of formula I which are aspartyl protease inhibitors: This invention also provides pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also provides methods for inhibition aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.
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申请公布号 |
US6127372(A) |
申请公布日期 |
2000.10.03 |
申请号 |
US19960424372 |
申请日期 |
1996.04.01 |
申请人 |
VERTEX PHARMACEUTICALS, INCORPORATED |
发明人 |
TUNG, ROGER DENNIS;SALITURO, FRANCESCO GERALD;DEININGER, DAVID D.;MURCKO, MARK ANDREW;NOVAK, PERRY MICHAEL;BHISETTI, GOVINDA RAO |
分类号 |
A61K31/18;A61K31/27;A61K31/34;A61K31/341;A61K31/425;A61K31/426;A61K31/44;A61K31/4427;A61K31/445;A61K31/495;A61P31/12;A61P43/00;C07C311/16;C07C311/29;C07C311/37;C07C311/41;C07C311/51;C07D211/60;C07D213/30;C07D213/38;C07D213/40;C07D213/70;C07D213/81;C07D213/82;C07D217/24;C07D217/26;C07D231/38;C07D233/54;C07D233/76;C07D233/84;C07D233/88;C07D233/90;C07D235/06;C07D235/28;C07D241/04;C07D249/18;C07D261/08;C07D263/22;C07D263/32;C07D263/56;C07D263/58;C07D277/06;C07D277/20;C07D277/26;C07D277/36;C07D277/44;C07D277/46;C07D307/10;C07D307/20;C07D307/33;C07D309/08;C07D309/10;C07D317/18;C07D317/34;C07D319/06;C07D333/36;C07D333/38;C07D333/48;C07D335/02;C07D401/06;C07D487/04;C07D493/04;C07D521/00;(IPC1-7):A61K31/351;A61K31/381;A61K31/419 |
主分类号 |
A61K31/18 |
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