7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl) piperidin-1-yl]-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use

摘要

These 7-[3-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen -4-one derivatives have the formula (I); wherein R is hydrogen, CHO, CH2OR2 or COOH; R1 is hydrogen or CH2OH; and R2 is alkyl having 1 to 4 carbon atoms with the proviso that one of substituents R and R1 should be hydrogen, as well as their pharmaceutically acceptable salts. The process for their preparation and the pharmaceutical compositions containing them are also described. The compounds are useful in the treatment of psychosis, schizophrenia and allergy.